Unstructured proteins: cellular complexity and human diseases (by Dr Madan Babu Mohan, Francis Crick Prize Lecture 2016)

source: The Royal Society     2017年1月4日
Unstructured proteins: cellular complexity and human diseases
If DNA is the blueprint of life, proteins are the building blocks. Research over the last century has shown that the shapes adopted by proteins determine their functions. Mutations that affect their shapes cause human diseases. However in recent decades, scientists have discovered that a large number of proteins do not adopt defined shapes. Nevertheless, these unstructured proteins perform functions that are critical for the survival of organisms.
In his talk Dr Mohan explores how unstructured proteins perform their functions, contribute to cellular complexity and cause human diseases including cancer and neurodegeneration.
The lecture was recorded on December 7 2016 at the Royal Society. For more events like this, see our schedule - http://ow.ly/KhTi306gTN1