Collective Dynamics of-, on- and around Filaments in Living Cells: Motors, MAPs, TIPs and Tracks (2017, ICTS Bangalore)

source: International Centre for Theoretical Sciences     2017年10月31日
Collective Dynamics of-, on- and around Filaments in Living Cells: Motors, MAPs, TIPs and Tracks
DATE: 28 October 2017 to 02 November 2017
VENUE: Ramanujan Lecture Hall, ICTS Bangalore
Our knowledge of cytoskeletal filaments, nucleic acid filaments (DNA and RNA) as well as their associated proteins is constantly expanding due to application of a range of recent biophysical techniques which has helped scientists to probe biophysical phenomena at molecular, cellular and tissue levels. Cytoskeletal filaments, particularly microtubules (MT) and filamentous actin (F-actin), not only provide mechanical strength to an eukaryotic cell but also form a fibrous network that serves at the network of tracks for transportation system of the cell. The dynamics of these filaments and the mechanisms of force generation by polymerization/depolymerization have been investigated experimentally as well as theoretically at multiple scales. Nucleic acid strands (DNA/RNA) are more flexible filaments. The hierarchical organization and dynamics of both cytoskeletal and nucleic acid filaments depend crucially on the proteins bound to these filaments.

Cytoskeletal motor proteins utilize the respective cytoskeletal filamentous tracks for directed, albeit noisy, movements that result in intracellular motility and/or contractility. The power and efficiency of these motors have been under intense investigation over the last two decades. Although most of the physical principles involved in the energy transduction and motility of the cytoskeletal motors and NA-based motors are common, most often these are investigated by two distinct communities of investigators, hence limited interaction between them. Exchange of ideas and methodologies between these two communities is likely to enrich both these areas of research. The main focus of this Discussion Meeting is to bring leading practitioners from both these areas on a single forum thereby catalyzing progress in both by comparing and contrasting the main conceptual challenges in these two areas. Sessions will be organized based on common underlying principles for cytoskeletal motors and NA-based motors looking at sub-, single- and multi-machine level. There will be 20 hours of lectures over the course of the meeting and the rest of the time will be reserved for interactions and discussions.
CONTACT US: cdflc@icts.res.in
PROGRAM LINK: https://www.icts.res.in/discussion-me...

55:30 Transporting cargo over long distance: insights from dynein/dynactin structures by Andrew Carter
51:24 Cargo crowding at actin-rich regions causes traffic jams in neurons by Sandhya P Koushika
1:09:55 Investigating Mitochondrial Dynamics in Fission Yeast using Chemical Kinetics by Francois Nedelec
54:26 How the Nucleus of Human Cells is Structured by Entropy by Dieter W Heermann
1:01:50 Dynamics of Translation by Joseph D Puglisi
54:03 Controlling enzyme and polymerase activity on single DNA molecules by Mark C Williams
55:12 Self-assembly,3D organization and dynamics of “tracks”: Physical models by Ranjith Padinhateeri
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1:06:15 Regulation of motor traffic and control of noisy gene expression by Debashish Chowdhury
55:09 Collective Dynamics Of Interacting Molecular Motors by Anatoly B Kolomeisky 
53:52 Motor Protein: To Cooperate or Not to Cooperate? by Manoj Gopalakrishnan
28:31 Additivity of Maximum Force Generated by Multiple Filaments or Motors by Tripti Bameta
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54:33 When less is more - Logistics of Axonal Transport by Kinesin-2 by Krishanu Ray
56:20 Traffic on filaments: Molecular motors under difficult conditions by Stefan Klumpp
1:00:07 How is motor transport regulated? Discovery of a new kinesin-family... by Steven Gross
1:02:01 The Dynamics of the Ribosome as Revealed by Joachim Frank
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42:25 Role of histone tails in NCP stability and chromatin assembly by Prabal K Maiti
58:23 Insights into DNA – protamines self-assembly by Yves Lansac
57:11 Selection of the initiator tRNA in the ribosomal by Umesh Varshney
40:24 Tug-of-war between CDK1 and PP2A during mitosis regulates proper by Sachin Kotak
47:31 The Dynein Catch Bond: Implications for cooperative transport by Mithun Kumar Mitra