Unstructured proteins: cellular complexity and human diseases (by Madan Babu Mohan)

source: The Royal Society    2016年12月7日
Francis Crick Prize Lecture 2016 given by Dr Madan Babu Mohan

If DNA is the blueprint of life, proteins are the building blocks. Research over the last century has shown that the shapes adopted by proteins determine their functions. Mutations that affect their shapes cause human diseases. However in recent decades, scientists have discovered that a large number of proteins do not adopt defined shapes. Nevertheless, these unstructured proteins perform functions that are critical for the survival of organisms.
Join Dr Mohan to discover how unstructured proteins perform their functions, contribute to cellular complexity and cause human diseases including cancer and neurodegeneration.
Image of intrinsically disordered protein. Copyright Dr Madan Babu Mohan.