source: YaleCourses Last updated on 2014年6月27日
Freshman Organic Chemistry II (CHEM 125B)
This is a continuation of Freshman Organic Chemistry I (CHEM 125a), the introductory course on current theories of structure and mechanism in organic chemistry for students with excellent preparation in chemistry and physics. This semester treats simple and complex reaction mechanisms, spectroscopy, organic synthesis, and some molecules of nature. Complete course materials are available at the Open Yale Courses website: http://oyc.yale.edu
1. Mechanism: How Energies and Kinetic Order Influence Reaction Rates 49:00
2. Peculiar Rate Laws, Bond Dissociation Energies, and Relative Reactivities 48:14
3. Rate and Selectivity in Radical-Chain Reactions 46:46
4. Electronegativity, Bond Strength, Electrostatics, and Non-Bonded Interactions 50:08
5. Solvation, H-Bonding, and Ionophores 47:10
6. Brønsted Acidity and the Generality of Nucleophilic Substitution 46:47
7. Nucleophilic Substitution Tools - Stereochemistry, Rate Law, Substrate, Nucleophile 51:56
8. Solvent, Leaving Group, Bridgehead Substitution, and Pentavalent Carbon 48:27
9. Pentavalent Carbon? E2, SN1, E1 48:05
10. Cation Intermediates. Alkenes: Formation, Addition, and Stability 51:15
11. Carbocations and the Mechanism of Electrophilic Addition to Alkenes and Alkynes 52:08
12. Nucleophilic Participation During Electrophilic Addition to Alkenes 49:05
13. Addition to Form Three-Membered Rings: Carbenoids and Epoxidation 50:55
14. Epoxide Opening, Dipolar Cycloaddition, and Ozonolysis 49:39
15. Metals and Catalysis in Alkene Oxidation, Hydrogenation, Metathesis, and Polymerization 50:36
16. Isoprenoids, Rubber, and Tuning Polymer Properties 46:27
17. Alkynes. Conjugation in Allylic Intermediates and Dienes 49:38
18. Linear and Cyclic Conjugation Theory. 4n+2 Aromaticity 47:46
19. Aromatic Transition States: Cycloaddition and Electrocyclic Reactions 49:13
20. Electronic and Vibrational Spectroscopy 49:47
21. Functional Groups and Fingerprints in IR Spectroscopy. Precession of Magnetic Nuclei 53:39
22. Medical MRI and Chemical NMR 49:21
23. Diamagnetic Anisotropy and Spin-Spin Splitting 48:20
24. Higher-Order Effects, Dynamics, and the NMR Time Scale 51:13
25. C-13 and 2D NMR. Electrophilic Aromatic Substitution 50:29
26. Aromatic Substitution in Synthesis: Friedel-Crafts and Moses Gomberg 50:49
27. Triphenylmethyl and an Introduction to Carbonyl Chemistry 45:34
28. Mechanism and Equilibrium of Carbonyl Reactions 49:04
29. Imines and Enamines. Oxidation and Reduction 50:02
30. Oxidation States and Mechanisms 46:58
31. Periodate Cleavage, Retrosynthesis, and Green Chemistry 46:08
32. Measuring Bond Energies: Guest Lecture by Prof. G. Barney Ellison 47:33
33. Green Chemistry. Acids and Acid Derivatives 49:20
34. Acids and Acid Derivatives 50:29
35. Acyl Insertions and [gr]α-Reactivity 48:49
36. [gr]α-Reactivity and Condensation Reactions 53:07
37. Proving the Configuration of Glucose and Synthesizing Two Unnatural Products 54:47
38. Review: Synthesis of Cortisone 52:09
1. Mechanism: How Energies and Kinetic Order Influence Reaction Rates 49:00
2. Peculiar Rate Laws, Bond Dissociation Energies, and Relative Reactivities 48:14
3. Rate and Selectivity in Radical-Chain Reactions 46:46
4. Electronegativity, Bond Strength, Electrostatics, and Non-Bonded Interactions 50:08
5. Solvation, H-Bonding, and Ionophores 47:10
6. Brønsted Acidity and the Generality of Nucleophilic Substitution 46:47
7. Nucleophilic Substitution Tools - Stereochemistry, Rate Law, Substrate, Nucleophile 51:56
8. Solvent, Leaving Group, Bridgehead Substitution, and Pentavalent Carbon 48:27
9. Pentavalent Carbon? E2, SN1, E1 48:05
10. Cation Intermediates. Alkenes: Formation, Addition, and Stability 51:15
11. Carbocations and the Mechanism of Electrophilic Addition to Alkenes and Alkynes 52:08
12. Nucleophilic Participation During Electrophilic Addition to Alkenes 49:05
13. Addition to Form Three-Membered Rings: Carbenoids and Epoxidation 50:55
14. Epoxide Opening, Dipolar Cycloaddition, and Ozonolysis 49:39
15. Metals and Catalysis in Alkene Oxidation, Hydrogenation, Metathesis, and Polymerization 50:36
16. Isoprenoids, Rubber, and Tuning Polymer Properties 46:27
17. Alkynes. Conjugation in Allylic Intermediates and Dienes 49:38
18. Linear and Cyclic Conjugation Theory. 4n+2 Aromaticity 47:46
19. Aromatic Transition States: Cycloaddition and Electrocyclic Reactions 49:13
20. Electronic and Vibrational Spectroscopy 49:47
21. Functional Groups and Fingerprints in IR Spectroscopy. Precession of Magnetic Nuclei 53:39
22. Medical MRI and Chemical NMR 49:21
23. Diamagnetic Anisotropy and Spin-Spin Splitting 48:20
24. Higher-Order Effects, Dynamics, and the NMR Time Scale 51:13
25. C-13 and 2D NMR. Electrophilic Aromatic Substitution 50:29
26. Aromatic Substitution in Synthesis: Friedel-Crafts and Moses Gomberg 50:49
27. Triphenylmethyl and an Introduction to Carbonyl Chemistry 45:34
28. Mechanism and Equilibrium of Carbonyl Reactions 49:04
29. Imines and Enamines. Oxidation and Reduction 50:02
30. Oxidation States and Mechanisms 46:58
31. Periodate Cleavage, Retrosynthesis, and Green Chemistry 46:08
32. Measuring Bond Energies: Guest Lecture by Prof. G. Barney Ellison 47:33
33. Green Chemistry. Acids and Acid Derivatives 49:20
34. Acids and Acid Derivatives 50:29
35. Acyl Insertions and [gr]α-Reactivity 48:49
36. [gr]α-Reactivity and Condensation Reactions 53:07
37. Proving the Configuration of Glucose and Synthesizing Two Unnatural Products 54:47
38. Review: Synthesis of Cortisone 52:09
