# click the top-left icon to select videos from the playlist
Instructors can request examination copies and sign up to download figures here:
http://www.sinauer.com/catalog/medical/evolutionary-medic...
This course is a survey of evolutionary insights that make important differences in medical research and clinical practice, including evolutionary mechanisms and the medical issues they affect. Individual genetic variation in susceptibility; evolutionary conflicts and tradeoffs in reproductive medicine; the evolution of antibiotic resistance and virulence in pathogens; emerging diseases; the evolution of aging; cancer as an evolutionary process.
0.0 - Welcome to Evolution and Medicine 10:40
1.1 - Evolutionary Thinking: Natural Selection 13:36
1.2 - Evolutionary Thinking: Random Evolution, The Role of Chance 20:45
1.3 - Evolutionary Thinking: Mismatch, a Major Cause of Maladaptation 8:47
1.4 - Evolutionary Thinking: Adaptation: Why it is Problematic and How to Recognize it 13:22
1.5 - Evolutionary Thinking: Styles of thought: Typological, Population, and Tree Thinking 12:30
2.1 - What is a patient? Ancient History 12:50
2.2 - What is a patient? Recent History 14:08
2.3 - What is a patient? Variation in disease resistance 11:10
2.4 - What is a patient? Variation in disease resistance 15:49
2.5 - What is a patient? Life history 15:22
2.6 - What is a patient? Plasticity and reaction norms 12:22
source: YaleCourses 上次更新日期：2015年9月2日
"Evolutionary Medicine" Sinauer Associates (2015) is the textbook that supports these lectures. Instructors can request examination copies and sign up to download figures here:
http://www.sinauer.com/catalog/medical/evolutionary-medic...
This course is a survey of evolutionary insights that make important differences in medical research and clinical practice, including evolutionary mechanisms and the medical issues they affect. Individual genetic variation in susceptibility; evolutionary conflicts and tradeoffs in reproductive medicine; the evolution of antibiotic resistance and virulence in pathogens; emerging diseases; the evolution of aging; cancer as an evolutionary process.
0.0 - Welcome to Evolution and Medicine 10:40
1.1 - Evolutionary Thinking: Natural Selection 13:36
1.2 - Evolutionary Thinking: Random Evolution, The Role of Chance 20:45
1.3 - Evolutionary Thinking: Mismatch, a Major Cause of Maladaptation 8:47
1.4 - Evolutionary Thinking: Adaptation: Why it is Problematic and How to Recognize it 13:22
1.5 - Evolutionary Thinking: Styles of thought: Typological, Population, and Tree Thinking 12:30
2.1 - What is a patient? Ancient History 12:50
2.2 - What is a patient? Recent History 14:08
2.3 - What is a patient? Variation in disease resistance 11:10
2.4 - What is a patient? Variation in disease resistance 15:49
2.5 - What is a patient? Life history 15:22
2.6 - What is a patient? Plasticity and reaction norms 12:22
2.7 - What is a patient? Tradeoffs 16:52
2.8 - What is a patient? Aging 16:33
2.9 - What is a patient? The unusual human life history 19:58
2.10 - What is a patient? Developmental origins of health and disease 10:02
2.11 - What is a patient? Development and the microbiota 14:49
2.12 - What is a patient? Recap 5:45
3.1 - What is a disease? Introduction 16:33
3.2 - What is a disease? Vulnerable to robust 9:55
3.3 - What is a disease? Fixed to adjustable 5:43
3.4 - What is a disease? History and mismatch 5:41
4.1 - Defenses: Origin in homeostasis 8:08
4.2 - Defenses: Types and costs 10:18
4.3 - Defenses: Specialized 1 10:11
4.4 - Defenses: Specialized 2 13:01
4.5 - Defenses: Diseases 7:19
4.6 - Defenses: Key characteristics 12:12
4.7 - Defenses: Strategies 1 8:17
4.8 - Defenses: Strategies 2 7:18
4.9 - Defenses: Innate immunity 7:16
4.10 - Defenses: Adaptive immunity 9:08
4.11 - Defenses: Clonal evolution 8:22
5.1 - Pathogen evolution: Virulence 1 9:39
5.2 - Pathogen evolution: Virulence 2 10:57
5.3 - Pathogen evolution: Managing the microbiota 14:43
5.4 - Pathogen evolution: Evading defenses 12:56
5.5 - Pathogen evolution: Resistance 13:06
5.6 - Pathogen evolution: Evolution-proof therapies 11:00
6.1 - Cancer: Introduction 8:36
6.2 - Cancer: Why we are susceptible 13:22
6.3 - Cancer: Clonal evolution 11:31
6.4 - Cancer: Phylogenetic insights 10:33
6.5 - Cancer: Evading the immune system 10:44
6.6 - Cancer: Adaptive chemotherapy 11:13
7.1 - Reproduction: The evolution of mammalian reproduction 17:10
7.2 - Reproduction: Invasive placentas and risk of metastatic cancer 14:49
7.3 - Reproduction: Parent-offspring conflict 10:21
7.4 - Reproduction: Menstruation 8:39
7.5 - Reproduction: Menopause 8:52
7.6 - Reproduction: Upright posture and childbirth 6:16
8.1 - Mismatch: Introduction 6:43
8.2 - Mismatch: Evidence from time and space 9:37
8.3 - Mismatch: Obesity 9:09
8.4 - Mismatch: type 2 diabetes 5:29
8.5 - Mismatch: Heart disease and cancer 7:50
8.6 - Mismatch: Hygiene and Old Friends 11:21
9.1 - Mental disorders: Explanations 5:49
9.2 - Mental disorders: Drug addiction 6:42
9.3 - Mental disorders: Anxiety, depression, and OCD 5:33
9.4 - Mental disorders: Autism and schizophrenia 9:21
10.1 - Population consequences of individual decisions 7:51
10.2 - The Great Transition and its impacts on health, disease, and selection 11:06
11.1 - Open questions 5:15
11.2 - Classical and evolutionary medicine 2:58
2.8 - What is a patient? Aging 16:33
2.9 - What is a patient? The unusual human life history 19:58
2.10 - What is a patient? Developmental origins of health and disease 10:02
2.11 - What is a patient? Development and the microbiota 14:49
2.12 - What is a patient? Recap 5:45
3.1 - What is a disease? Introduction 16:33
3.2 - What is a disease? Vulnerable to robust 9:55
3.3 - What is a disease? Fixed to adjustable 5:43
3.4 - What is a disease? History and mismatch 5:41
4.1 - Defenses: Origin in homeostasis 8:08
4.2 - Defenses: Types and costs 10:18
4.3 - Defenses: Specialized 1 10:11
4.4 - Defenses: Specialized 2 13:01
4.5 - Defenses: Diseases 7:19
4.6 - Defenses: Key characteristics 12:12
4.7 - Defenses: Strategies 1 8:17
4.8 - Defenses: Strategies 2 7:18
4.9 - Defenses: Innate immunity 7:16
4.10 - Defenses: Adaptive immunity 9:08
4.11 - Defenses: Clonal evolution 8:22
5.1 - Pathogen evolution: Virulence 1 9:39
5.2 - Pathogen evolution: Virulence 2 10:57
5.3 - Pathogen evolution: Managing the microbiota 14:43
5.4 - Pathogen evolution: Evading defenses 12:56
5.5 - Pathogen evolution: Resistance 13:06
5.6 - Pathogen evolution: Evolution-proof therapies 11:00
6.1 - Cancer: Introduction 8:36
6.2 - Cancer: Why we are susceptible 13:22
6.3 - Cancer: Clonal evolution 11:31
6.4 - Cancer: Phylogenetic insights 10:33
6.5 - Cancer: Evading the immune system 10:44
6.6 - Cancer: Adaptive chemotherapy 11:13
7.1 - Reproduction: The evolution of mammalian reproduction 17:10
7.2 - Reproduction: Invasive placentas and risk of metastatic cancer 14:49
7.3 - Reproduction: Parent-offspring conflict 10:21
7.4 - Reproduction: Menstruation 8:39
7.5 - Reproduction: Menopause 8:52
7.6 - Reproduction: Upright posture and childbirth 6:16
8.1 - Mismatch: Introduction 6:43
8.2 - Mismatch: Evidence from time and space 9:37
8.3 - Mismatch: Obesity 9:09
8.4 - Mismatch: type 2 diabetes 5:29
8.5 - Mismatch: Heart disease and cancer 7:50
8.6 - Mismatch: Hygiene and Old Friends 11:21
9.1 - Mental disorders: Explanations 5:49
9.2 - Mental disorders: Drug addiction 6:42
9.3 - Mental disorders: Anxiety, depression, and OCD 5:33
9.4 - Mental disorders: Autism and schizophrenia 9:21
10.1 - Population consequences of individual decisions 7:51
10.2 - The Great Transition and its impacts on health, disease, and selection 11:06
11.1 - Open questions 5:15
11.2 - Classical and evolutionary medicine 2:58
